These letters were assembled by Lady Paget as a collection of autographs. Most are addressed to Paget, and their subjects include medicine, science, and family.

There are 153 letters in this collection, many addressed to Aubrey Lackington Moore, an English writer who tried to reconcile evolution and traditional Christianity. Some letters discuss scientific questions of the day, while others are formal social notes. Also includes 24 clipped signatures, inlcuding those of Sir Henry Wentworth Acland; Goerge Bentham; H. A. Bruce; S. H. Butcher; Matthewss Duncan; Percy Gardner; George Gritchett; G. Grote; Alfred Cort Haddon; Sir Prescott Gardner Hewitt; William Guyer Hunter; Thomas Henry Huxley; John Lingard; Thomas Babington Macauley; Miss K. Aubrey Moore; Louis Pasteur; Sir John Russell Reynolds, bart.; Thomas Smith; James Leigh Strachan-Davidson; Agnes Strickland; and Arthur Thomason.

This collection contains correspondence on natural history, expecially mollusks, fishes, and birds, and on medicine and social affairs, with references to the British Museum of Natural History. Also included are a paper by Owen on dinosaurs and a synopsis of a course of lectures, 1857.

One of the most important natural historians in nineteenth century Britain, Charles Darwin provided the first compelling mechanism to account for organismal evolutionary change. Although lacking a coherent model of heredity, Darwin's natural selection has exerted an enormous influence over the biological sciences and since the introduction of Mendelian genetics, had remained the key unifying principle in the discipline. The APS Darwin Papers are a large a valuable assemblage of Darwin's correspondence with scientific colleagues, including Charles Lyell and George J. Romanes. They are included in the print version of the Correspondence of Charles Darwin (Cambridge Univ. Press).